pI: 6.7489 |
Length (AA): 457 |
MW (Da): 53927 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 421 | 1ho8 (A) | 27 | 478 | 21.00 | 0 | 1 | 1.15 | -1.15 |
4 | 421 | 1ho8 (A) | 27 | 478 | 21.00 | 0 | 1 | 1.25 | -0.94 |
11 | 451 | 1ho8 (A) | 4 | 478 | 22.00 | 0 | 1 | 1.13339 | -0.06 |
113 | 284 | 2pml (X) | 4 | 183 | 29.00 | 0.44 | 0.52 | 0.357968 | 1.99 |
158 | 445 | 4plq (A) | 11 | 290 | 12.00 | 0 | 0.99 | 0.839297 | -0.77 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_127797)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G42050 | V-type proton ATPase subunit H |
Babesia bovis | BBOV_III004100 | conserved hypothetical protein |
Brugia malayi | Bm1_04435 | hypothetical protein |
Caenorhabditis elegans | CELE_F52E1.10 | Protein VHA-18 |
Caenorhabditis elegans | CELE_T14F9.1 | Protein VHA-15 |
Cryptosporidium hominis | Chro.20424 | vacuolar ATP synthase subunit h |
Cryptosporidium parvum | cgd2_3960 | vacuolar ATP synthase subunit 54kD |
Dictyostelium discoideum | DDB_G0274553 | vacuolar ATP synthase subunit H |
Drosophila melanogaster | Dmel_CG17332 | Vacuolar H[+]-ATPase SFD subunit |
Echinococcus granulosus | EgrG_000339600 | Vacuolar H ATPase SFD subunit |
Entamoeba histolytica | EHI_068750 | vacuolar ATP synthase subunit H, putative |
Echinococcus multilocularis | EmuJ_000339600 | Vacuolar H+ ATPase SFD subunit |
Giardia lamblia | GL50803_14961 | Vacuolar ATP synthase subunit H |
Homo sapiens | ENSG00000047249 | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
Leishmania braziliensis | LbrM.21.1580 | ATP synthase, putative |
Leishmania donovani | LdBPK_211590.1 | ATP synthase, putative |
Leishmania infantum | LinJ.21.1590 | ATP synthase, putative |
Leishmania major | LmjF.21.1340 | ATP synthase, putative |
Leishmania mexicana | LmxM.21.1340 | ATP synthase, putative |
Loa Loa (eye worm) | LOAG_03309 | vacuolar h ATPase 15 |
Mus musculus | ENSMUSG00000033793 | ATPase, H+ transporting, lysosomal V1 subunit H |
Neospora caninum | NCLIV_003220 | vacuolar ATP synthase subunit h, putative |
Oryza sativa | 9272111 | Os07g0549700 |
Plasmodium berghei | PBANKA_1405100 | V-type proton ATPase subunit H, putative |
Plasmodium falciparum | PF3D7_1306600 | V-type proton ATPase subunit H, putative |
Plasmodium knowlesi | PKNH_1406800 | V-type proton ATPase subunit H, putative |
Plasmodium vivax | PVX_122165 | hypothetical protein, conserved |
Plasmodium yoelii | PY02592 | Drosophila melanogaster SD07421p, putative |
Saccharomyces cerevisiae | YPR036W | H(+)-transporting V1 sector ATPase subunit H |
Schistosoma japonicum | Sjp_0301850 | ko:K02144 V-type H+-transporting ATPase 54 kD subunit, putative |
Schistosoma mansoni | Smp_117810 | vacuolar ATP synthase subunit h |
Schistosoma mansoni | Smp_015070.2 | vacuolar ATP synthase subunit h |
Schistosoma mansoni | Smp_015070.1 | vacuolar ATP synthase subunit h |
Schmidtea mediterranea | mk4.001274.06 | |
Trypanosoma brucei gambiense | Tbg972.10.750 | ATP synthase, putative |
Trypanosoma brucei | Tb927.10.730 | ATP synthase, putative |
Trypanosoma brucei | Tb11.v5.0822 | ATP synthase, putative |
Trypanosoma congolense | TcIL3000_10_590 | ATP synthase, putative |
Trypanosoma cruzi | TcCLB.506855.80 | ATP synthase, putative |
Trypanosoma cruzi | TcCLB.508781.20 | ATP synthase, putative |
Toxoplasma gondii | TGME49_208590 | vacuolar ATP synthase subunit 54kD, putative |
Theileria parva | TP03_0033 | vacuolar ATP synthase subunit H, putative |
Trichomonas vaginalis | TVAG_262750 | vacuolar ATP synthase subunit H, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.730 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.730 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.730 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.730 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F52E1.10 | Caenorhabditis elegans | sterile | wormbase |
CELE_T14F9.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T14F9.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T14F9.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T14F9.1 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1405100 | Plasmodium berghei | Essential | plasmo |
TGME49_208590 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.